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KMID : 0391520160240040217
Journal of the Korean Child Neurology Society
2016 Volume.24 No. 4 p.217 ~ p.222
The Effects of Serum Sodium Concentration on Occurrence and Recurrence of Febrile Seizures
Seo In-Ae

Seo Eun-Young
Cho Seung-Man
Lee Dong-Seok
Choi Sung-Min
Kim Doo-Kwon
Abstract
Purpose: The aim of this study is to elucidate the effects of serum sodium concentration on occurrence and recurrence of febrile seizures based on case-control study.

Methods: We reviewed retrospectively clinical records of 150 inpatients with febrile seizures and 150 inpatients with febrile illness without seizure aged from 6 months to 5 years in the Pediatric Department of Dongguk University Gyeongju Hospital between January 2014 and February 2016. The age, sex and serum sodium concentration of the patient group were compared with those of control group. Patient group was divided into simple vs complex febrile seizure group, non-repeated vs repeated febrile seizure group, non-recurrent vs recurrent febrile seizure group, and the serum sodium concentration of each group were analysed statistically.

Results: The mean serum sodium concentration (137.46¡¾2.72 mmol/L) of patient group was significantly lower (P<0.05) than that of control group (139.34¡¾2.14 mmol/L). The mean serum sodium concentration of simple febrile seizure group (137.47¡¾2.53 mmol/L) was not significantly different (P=0.998) from that of complex febrile seizure group (137.43¡¾3.77 mmol/L). The mean serum sodium concentration of repeated febrile seizure group (136.56¡¾3.2 mmol/L) was lower than that of non-repeated febrile seizure group (137.56¡¾2.66 mmol/L), but not significant (P= 0.272). The mean serum sodium concentration of recurrent febrile seizure group (136.60¡¾2.02 mmol/L) was significantly lower (P=0.006) than that of non-recurrent febrile seizure group (137.89¡¾2.93 mmol/L). The mean serum sodium concentration of all these subgroups were significantly lower than that of control group.

Conclusion: Low serum sodium concentration may have an effect on the increase of occurrence and recurrence of febrile seizures.
KEYWORD
Recurrence, Febrile seizures, Hyponatremia
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